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Posted: Thu Oct 09, 2008 12:29 pm Post subject: AnaSpec Introduces Histone GO™ Peptides
San Jose, CA – October 8, 2008
The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds. Covalent modification on the amino terminal of the core histones through de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and exquisitely regulate gene expression.1-3 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.2
AnaSpec, one of the world’s largest provider of on-demand peptides is pleased to announce the rapid expansion of our histone peptide selection. Histone GO™ Peptides include sequences that are acetylated and di- or tri-methylated.
AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.
For more information visit www.anaspec.com
1. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
2. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
3. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
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