Joined: 15 Aug 2006
Location: 34801 Campus Drive, Fremont, CA 94555
Posted: Tue Dec 15, 2009 6:58 pm Post subject: AnaSpec Introduces New OVA GO™ Peptides
Fremont, CA – December 15, 2009
Continuing to expand its collection of ready-to-go peptides, AnaSpec has released a new selection of OVA peptides in the GO™ peptide format.
Proteolytic processing of proteins in the cytoplasm generates peptide epitopes that are generally 8-10 amino acids in length. The binding of these peptides to the surface major histocompatibility complex (MHC) class I molecules and subsequent presentation to T-cells elicits an immune response.1 A model antigen extensively studied is Ovalbumin (OVA). OVA is processed to the presenting octapeptide (257-264), SIINFEKL, through proteasomal and non-proteasomal activities.2 As with peptides naturally presented by H-2Kb, SIINFEKL has on its 5th position an amino acid with an aromatic side chain (Phe) and on the 8th position, an aliphatic side chain (Leu).3 Variants of this peptide consisting of substituting different amino acids at strategic positions have yielded valuable information on the interaction of this peptide and the MHC complex.3
The use of AnaSpec’s SIINFEKL has been reported in peer-reviewed journals since 1997. We are pleased that researchers have trusted us to provide this important peptide. We are also pleased to announce the recent release of variants of this peptide.
1. Heemel, M & H. Ploegh Annu. Rev. Biochem. 64, 463 (1995).
2. Beninga, J. et al. J. Biol. Chem. 273, 18734 (1998).
3. Hin, S. et al. J. Biol. Chem. 276, 48790 (2001).
AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and antibodies.
AnaSpec recently joined forces with Eurogentec to provide an even broader spectrum of products and services to serve the worldwide life science community.
Eurogentec is a leading global supplier of innovative reagents, kits, specialty products and custom services to scientists in the life science, biotechnology, pharmaceutical and diagnostic markets. Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications. Our ISO13485:2003-certified manufacturing facilities in Belgium provides a wide range of high value oligonucleotide-based components for diagnostic and therapeutic applications. Eurogentec’s Belgium manufacturing facility is complemented by additional production facilities in North America and Japan. Eurogentec is also an experienced Contract Manufacturing Organization (CMO) for Biopharmaceuticals, operating a full-service, state-of-the-art GMP facility in Belgium.
Eurogentec is a privately held company headquartered in Liège, Belgium, with subsidiaries in North America, France, Germany, the UK, the Netherlands and Switzerland and has additional production facilities in North America, Japan and Singapore. Eurogentec employs 400+ people globally.
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