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Posted: Mon Oct 16, 2006 2:46 pm Post subject: Homo-Amino Acids Provide Novel Options for Drug Discovery
The prefixing of “homo” to the name of an amino acid indicates the addition of a methylene (CH2) group on the a-carbon of an amino acid1,2. These are used for creating peptide analogs that have may have altered biological activity.
An example is shown in Shimizu’s paper3 where certain amino acids in the parathyroid hormone peptide PTH (1-14) have been substituted with Aib (aminoisobutyric acid) and homoarginine. This shorter N-terminal fragment is found to be as potent as PTH (1-34) for stimulating cAMP formation in PTH-1 receptor-expressing cells.
AnaSpec, a leading provider of integrated proteomics solutions, provides a source of homo-amino acids suited for either drug discovery or investigation of peptide biological activity.
· Fmoc-homoproline-OH or Fmoc-Pip-OH
For more information visit www.anaspec.com
1. Internet. http://www.chem.qmul.ac.uk/iupac/AminoAcid/AA1n2.html#AA23/ Sept. 27, 2006.
2. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC). Nomenclature of Organic Chemistry, Section F: Natural Products and Related Compounds, Recommendations 1976, Eur. J. Biochem. 86, 1 (1978).
3. Shimizu, N. et al. J. Bone & Mineral Res. 19, 2078 (2004). _________________ Ping Yang
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