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Ghrelin and Obestatin Peptides Linked to Appetite

 
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anaspec



Joined: 15 Aug 2006
Posts: 238
Location: 34801 Campus Drive, Fremont, CA 94555

PostPosted: Wed Dec 06, 2006 2:51 pm    Post subject: Ghrelin and Obestatin Peptides Linked to Appetite Reply with quote

In 1999, Kojima and his group (1) reported the discovery of a growth hormone secretagogue that is involved in the release of growth hormone from the anterior pituitary through activation of the growth hormone secretagogue receptor (GHS-R).

They termed it Ghrelin (ghre from a Proto-Indo-European root meaning to grow). Ghrelin, a 28-amino-acid peptide hormone produced by the stomach in mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity). It stimulates appetite and food intake and decreases fat utilization. The secretion of ghrelin is augmented under conditions of both gastric emptying and filling, and its release stimulated by intestinal hormones (1-5).

In 2005, Hsueh’s group (6) found a peptide fragment from the same ghrelin gene that has opposite effects from those of Ghrelin. This they named Obestatin (obedere from Latin, meaning to devour, and statin denoting suppression). Obestatin binds to the orphan G protein-coupled receptor GPR39 and suppresses food intake, inhibits jejunal contraction and decreases body weight gain (6).

AnaSpec, a leading provider of integrated proteomics solutions, offers a wide range of ghrelin and obestatin peptides for research use.

Ghrelins
· Bovine
· Human
· Rat

[Des-Octanoyl]-Ghrelin
· Human
· Rat

Labeled Human Ghrelins – may be used for ligand-receptor intereaction studies5
· Biotin-Labeled
· FAM-Labeled
· TAMRA-Labeled

Obestatins
· Human
· Rat

For more information visit www.anaspec.com

References:
1. Kojima, M. et al. Nature 402, 656 (1999).
2. Kleinz, MJ. et al. Cardiovasc Res. 69, 227 (2006).
3. Murakami, N. et al. J. Endocrinol. 174, 283 (2002).
4. Nishi, Y. et al. Endocrinol. 146, 2709 (2005).
5. Cowley, MA. et al. Neuron 37, 649 (2003).
6. Zhang, JV. et al. Science 310, 996 (2005).
_________________
Ping Yang
Marketing Speialist
34801 Campus Drive
Fremont, CA 94555
1-800-452-5530 (Toll free)
1-510-791-9560 (Tel)
1-510-791-9572 (Fax)
ping@anaspec.com
www.anaspec.com
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