Joined: 15 Aug 2006
Location: 34801 Campus Drive, Fremont, CA 94555
Posted: Tue Aug 15, 2006 3:11 pm Post subject: AnaSpec, Inc. Carries A Vast Collection of Amyloid Peptides
AnaSpec has been providing b-Amyloid peptides to leading Alzheimer’s researchers for almost 10 years. As interest in amyloid peptides continues to grow, AnaSpec has developed an extensive selection of catalog amyloid peptides to match that interest. Equipped with expertise in both peptide synthesis and detection technologies, AnaSpec presents one of the world’s most comprehensive collection of amyloid peptides.
ß-Amyloid (Aß) peptides, made up of long, insoluble ordered fibers, are glycoproteins deposited extracellularly in tissues in amyloidosis. These peptides are generated as cleavage products from the membrane protein, Amyloid Precursor Protein (APP) by two proteases, b-secretase and g-secretase. Aßs are amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28 ) and a hydrophobic C-terminal (residues 29 to 40), the latter corresponding to a part of the transmembrane domain of APP. These insoluble amyloid deposits found in Alzheimer’s diseased brains have been the subject of increased interest for Alzheimer’s treatment (reviewed in 1, 2).
The AnaSpec collection includes:
· Aßs of various lengths
· Amino acid-substituted Aßs
· Dye-labeled Aßs
· Biotin-labeled Aßs
· TFA salt forms (Standard form, unless otherwise specified)
· Sodium forms
· HCl forms
· iAb5p and other-Aß inhibitors
· Secretase fluorescent resonance energy transfer (FRET) substrates and inhibitors
· APP Fragments
Full listing of amyloid peptides available at [url]www.anaspec.com[/url]
1. Selkoe DJ. Nature 399, A23 (1999).
2. Suh, Y-H. and F. Checler. Pharma. Rev. 54, 469 (2002). _________________ Ping Yang
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