Press Release Forum [pressreleaseforum.com] Forum Index

Press Release Forum [pressreleaseforum.com]
Free Press Release Distribution

A site of EPR Network

 FAQFAQ   SearchSearch   MemberlistMemberlist   UsergroupsUsergroups   RegisterRegister 
 ProfileProfile   Log in to check your private messagesLog in to check your private messages   Log inLog in 

Real Time Press Release Distribution is here. Try it out, it's free!

 

AnaSpec Synthesizes MOG Peptides for MS Research

 
Post new topic   Reply to topic    Press Release Forum [pressreleaseforum.com] Forum Index -> Biotech Press Releases
View previous topic :: View next topic  
Author Message
anaspec



Joined: 15 Aug 2006
Posts: 238
Location: 34801 Campus Drive, Fremont, CA 94555

PostPosted: Mon Sep 18, 2006 7:03 pm    Post subject: AnaSpec Synthesizes MOG Peptides for MS Research Reply with quote

Myelin/oligodendrocyte glycoprotein (MOG) is a 26- to 28-kDa protein that was first described as a target antigen for the autoimmune demyelination response observed in animals immunized with CNS homogenates. It is a member of the immunoglobulin superfamily expressed in the central nervous system (CNS) and located within the MHC. Found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the CNS, it is thought to be targeted by the autoimmune T cell response in multiple sclerosis (MS). Although this protein is a minor component of myelin proteins, MOG is a potent autoantigen which contributes extensively to the anti-myelin response and primary inflammatory demyelination in autoimmune diseases. Several lines of evidence suggest that autoreactive antibodies are important in MS pathogenesis, however the pathophysiological significance of MOG-specific autoantibodies in MS/EAE is still controversial. Subtle changes in MOG sequences dramatically influence disease susceptibility and T cell responses in vitro.

In its continuing effort to provide research solutions for MS, AnaSpec offers MOG (35 - 55), mouse, rat, a key peptide that induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
· MOG (35-55), mouse, rat

Other fragments of MOG (35-55)*:
· MOG 35-52
· MOG 35-53
· MOG 35-51
· MOG 38-55
· MOG 38-53
· MOG 40-55
· MOG 41-54
· MOG 42-54
· MOG 43-54
· MOG 45-54
· MOG 46-54

* For more information about these additional MOG fragments, contact service@anaspec.com

For more information, visit www.anaspec.com

References:
1. Delarasse, C. et al. J. Clin. Invest. 112, 544 (2003)
2. Pham-Dinh, D. et al. Proc. Natl. Acad. Sci. USA 3 90, 7990 (1993)
3. Carotenuto, A. et al. J. Med. Chem. 44, 2378 (2001)
4. Bernard, CC. et al. J. Mol. Med. 75, 77 (1997)
5. Iglesias, A. Glia 36, 220 (2001)
6. von Budingen, HC. et al. J. Clin. Immunol. 21, 155 (2001)
_________________
Ping Yang
Marketing Speialist
34801 Campus Drive
Fremont, CA 94555
1-800-452-5530 (Toll free)
1-510-791-9560 (Tel)
1-510-791-9572 (Fax)
ping@anaspec.com
www.anaspec.com
Back to top
View user's profile Send private message Send e-mail Visit poster's website
Display posts from previous:   
Post new topic   Reply to topic    Press Release Forum [pressreleaseforum.com] Forum Index -> Biotech Press Releases All times are GMT - 4 Hours
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum

Submit Press Release (Free)Submit Press Release