Joined: 15 Aug 2006
Location: 34801 Campus Drive, Fremont, CA 94555
Posted: Mon Oct 09, 2006 3:32 pm Post subject: Calcium Homeostasis and the Roles of PTH & Calcitonin Pe
Calcium (Ca2+) plays a key role in numerous important physiological processes with the amount of ionized calcium in blood plasma tightly regulated within a narrow range (Reviewed in Ref 1).
Calcium homeostasis is finely regulated by Parathyroid Hormone (PTH), Calcitonin and Vitamin D. Briefly, a decrease in calcium concentration in the blood, triggers the release of PTH, an 84-amino acid hormone, from the parathyroid glands. An increase, however, causes the release of Calcitonin, a 32-amino acid protein from the thyroid parafollicular cells (C-cells). Vitamin D helps in the absorption of Ca2+ from the intestine.
AnaSpec, a leading provider of integrated proteomics solutions, carries a wide range of peptide products to support researchers working with Ca2+ metabolism.
· Human, Bovine, and Rat - the amino-terminal PTH (1-34) fragment satisfies the structural requirements for all known biological activities of parathyroid hormone PTH(1-84)]2
· Biotinylated, FAM-labeled, and Lys-biotin-labeled - used as probes in studies such as characterization of parathyroid hormone receptors3,4
Parathyroid Hormone Related Protein (PTHrP)
· 1-34, 1-40, and 7-34 peptide fragments - responsible for most of humoral hypercalcemia of malignancy (HHM)5
· Salmon, Human, Eel, and others
· Biotin-labeled and Fluorescein-labeled
Other Calcitonin related peptides:
1. Khan, MM. and JP. Desborough, Pharmacology 19, 1 (2005).
2. Stevenson, RW and JA Parsons, J. Endo. 97, 21 (1983).
3. Newman, W. et al. J. Biol. Chem. 264, 16359 (1989).
4. Brennan, DP. and MA. Levine, J. Biol. Chem. 262, 14795 (1987).
5. Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988). _________________ Ping Yang
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