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Homo-Amino Acids Provide Novel Options for Drug Discovery

 
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anaspec



Joined: 15 Aug 2006
Posts: 238
Location: 34801 Campus Drive, Fremont, CA 94555

PostPosted: Mon Oct 16, 2006 2:46 pm    Post subject: Homo-Amino Acids Provide Novel Options for Drug Discovery Reply with quote

The prefixing of “homo” to the name of an amino acid indicates the addition of a methylene (CH2) group on the a-carbon of an amino acid1,2. These are used for creating peptide analogs that have may have altered biological activity.

An example is shown in Shimizu’s paper3 where certain amino acids in the parathyroid hormone peptide PTH (1-14) have been substituted with Aib (aminoisobutyric acid) and homoarginine. This shorter N-terminal fragment is found to be as potent as PTH (1-34) for stimulating cAMP formation in PTH-1 receptor-expressing cells.

AnaSpec, a leading provider of integrated proteomics solutions, provides a source of homo-amino acids suited for either drug discovery or investigation of peptide biological activity.

Homo-Amino Acids:
· Fmoc-homoarginine(Pbf)-OH
· Fmoc-S-trityl-L-homocysteine
· Boc-S-trityl-L-homocysteine
· Fmoc-L-homophenylalanine
· Fmoc-D-homophenylalanine
· Fmoc-homoproline-OH or Fmoc-Pip-OH
For more information visit www.anaspec.com

References:
1. Internet. http://www.chem.qmul.ac.uk/iupac/AminoAcid/AA1n2.html#AA23/ Sept. 27, 2006.
2. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC). Nomenclature of Organic Chemistry, Section F: Natural Products and Related Compounds, Recommendations 1976, Eur. J. Biochem. 86, 1 (1978).
3. Shimizu, N. et al. J. Bone & Mineral Res. 19, 2078 (2004).
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