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Describes Synthesis of Hydrocarbon-Stapled Peptides

 
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anaspec



Joined: 15 Aug 2006
Posts: 238
Location: 34801 Campus Drive, Fremont, CA 94555

PostPosted: Thu Jul 12, 2007 12:03 pm    Post subject: Describes Synthesis of Hydrocarbon-Stapled Peptides Reply with quote

July 10, 2007 – Montreal, QC, Canada

At the 2007 annual conference of the American Peptide Society, AnaSpec presented a technical poster that described the facile synthesis of a hydrocarbon-stapled peptide. Asymmetric synthesis of (S)-Fmoc-α-(2’-pentenyl)-alanine was successfully accomplished via an Ala-Ni (II)-BPB-complex [3] in three steps with a 40% total yield.

The modified hydrocarbon-stapled peptides are helical, relatively protease-resistant, and cell-permeable peptides that bind with increased affinity for its target, and may provide a useful strategy for experimental and therapeutic modulation of protein-protein
interactions in many signaling pathways.

For more information visit www.anaspec.com

Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry. Established in 1993, AnaSpec's headquarters and manufacturing facilities are located in San Jose, CA.
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Ping Yang
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34801 Campus Drive
Fremont, CA 94555
1-800-452-5530 (Toll free)
1-510-791-9560 (Tel)
1-510-791-9572 (Fax)
ping@anaspec.com
www.anaspec.com
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